Well, the use case for create-react-app is for JavaScript/React developers to create a new JSX-based React application and most of those JavaScript/React develo

Well, the use case for create-react-app is for JavaScript/React developers to create a new JSX-based React application and most of those JavaScript/React developers… - have no idea what you are talking about, - have no desire to use/learn anything else than JavaScript or something really close like TypeScript and will barf at the sight of ClosureScript's syntax, - like their JSX and will barf at the sight of reagent's syntax, - are used to infinitely large node_modules directories anyway. The promise of re-frame is definitely interesting, but comparing directory size won't get you far when the real obstacles to adoption are elsewhere.