7 ms·

A carnivorous diet (meat only, zero carbs) would accomplish the same without the pharmacological drawback. Been on the diet for over a year and have never felt

A carnivorous diet (meat only, zero carbs) would accomplish the same without the pharmacological drawback. Been on the diet for over a year and have never felt better in my life.

toomuchtodo 7y ago
Keto diet is very similar.
justsomeone88 7y ago
Keto/carnivore is incredibly dangerous to the human body in the long run (5+ years out). Excess protein (in fact, even in the amounts society recognizes as "normal") is bad for you. https://www.youtube.com/watch?v=2R07FL1wVo4 https://www.youtube.com/watch?v=2R07FL1wVo4
- deleted 7y ago
  [deleted]
- Mountain_Skies 7y ago
  The Vegetarian Society of Hawaii isn't exactly an unbiased source. Maybe for balance we should post a video from the Texas Cattlemen's Association.
  - stevespang 7y ago
    Oh yeah, those who murder innocent animals for profit by the hundreds of thousands . . . may they glow in agony in the internal fires of hell
- reggintoggaf 7y ago
  No it is not.
- koboll 7y ago
  That video has a lot of pseudoscience ("leaky gut" syndrome, paleo humans never ate meat, etc.) so I'm inclined to distrust it entirely
  - Madmallard 7y ago
    Leaky gut pseudoscience :) There's literally thousands of articles on it on pubmed. Paleo humans never ate meat sounds silly, though.
- Zelphyr 7y ago
  I've been on Keto for almost two years and recently had someone adamantly scold me about how bad it is for my brain. My n=1 suggests otherwise. Things like focus and mood are all significantly better than they were before. Physical and mental stamina have both increased. I went from an "Obese" body fat percentage to "Athletic" in six months. But still, I gave him the benefit of the doubt and sincerely asked him, and ask others here, "Please provide me with studies that show that it's 'horrible for the brain'." I don't mean that to be snarky. I've looked and haven't been able to find the studies. Maybe I've been looking in the wrong places and I would love to read the studies* that show how bad it is. Towards the end of the conversation with this guy I found it amusing that he stopped chiding me long enough to ask, "So... wait, what is Keto?" * Peer-reviewed, scientifically rigorous studies only please.
  - mark-r 7y ago
    Maybe your brain function is sufficiently impaired that you can't find the studies? Seriously, I had an accident in March that necessitated a brain operation and left me in the hospital for over a month. The most surprising after-effect is that I can't always predict or recognize the symptoms arising from that.
    - Zelphyr 7y ago
      My dad had a brain operation a few years ago. His recovery has been somewhat slow and wasn't always smooth but it also wasn't as bad as I think we all expected. Brains are mysterious organs. I wish you all the best in your recovery.
  - usaphp 7y ago
    > things like focus and mood are all significantly better then before... Was your keto diet the only change in your life? Going from obese to athletic in 6 months probably includes some other good habits like going to gym/physical activity and good sleep etc. So maybe your change in a lifestyle helped you improve you mood and focus, not necessarily the keto diet in particular?
    - 7y ago
- i_am_nomad 7y ago
  I’m sorry, YouTube is too academic and dense. Could you post a TikTok or a meme with the same info?
  - decebalus1 7y ago
    Dear stranger, I was/am having a pretty bad day and then I read your comment and laughed out loud for the first time since yesterday. Thanks!
    - stephenSinniah 7y ago
      Let's save these kind of interactions for reddit, please.
topmonk 7y ago
No, it wouldn't. Your brain needs glucose to survive and your body will manufacture it if it's not present. If you actually were able to accomplish what you're saying, you'd be braindead.
- frisco 7y ago
  You need ATP. The Krebs cycle can manufacture it from either ketone bodies or from glucose.
  - topmonk 7y ago
    You also need glucose. With a blood glucose level of zero, you die.
    - frisco 7y ago
      Again, the important thing is ATP, and you can get it from either glucose or ketone bodies: > In fact, the late George Cahill did an experiment many years ago (probably would never get IRB approval to do such an experiment today) to demonstrate how ketones can offset glucose in the brain. Subjects with very high levels of B-OHB (about 5-7 mM) were injected with insulin until glucose levels reached 1 mM (about 19 mg/dL)! A normal person would fall into a coma at glucose levels below about 40 mg/dL and die by the time blood glucose reached 1 mM. These subjects were completely asymptomatic and 100% neurologically functional. https://peterattiamd.com/ketosis-advantaged-or-misunderstood-state-part-i/ https://peterattiamd.com/ketosis-advantaged-or-misunderstood...
      - maximente 7y ago
        no, you're both oversimplifying. the brain needs some glucose to sustain itself, a little bit, according to present day research. yes, it can principally function on ketones but not /exclusively/. it is not controversial that the brain can survive long periods of time on principally ketones, but what has not yet been proven (for obvious ethical reasons) is whether or not the brain can sustain itself with absolutely no glucose whatsoever. again, the ratios are key. i'm not contesting that ketones can be used as the principal fuel source, just that "the important thing is ATP" because the brain needs some glucose. https://www.ncbi.nlm.nih.gov/books/NBK28048/ https://www.ncbi.nlm.nih.gov/books/NBK28048/
itchyouch 7y ago
with protein only, the protein goes through gluconeogensis and the protein is converted into glucose, whereas in keto, the fat is used as fat...
- arcticbull 7y ago
  The glycerol backbones in triglycerides also undergo gluconeogenesis.
  - tryptophan 7y ago
    Yes. Red blood cells literally can only eat glucose. Without it you would be super dead. I find it amusingly absurd how so many people here seem convinced that our primary food source is somehow a poison. People with 0 carbs in their blood are colloquially known as 'dead'. I wonder if people even know what ketone bodies are... They are a downstream product of glucose processing(also downstream of fats - the inputs are different but the outputs are identical in a few ways), acetyl-coA, stuck together for bloodstream transport with the coenzyme temporarily removed.
    - arcticbull 7y ago
      Glucose is definitely food for humans, I think what the discussions here and more generally in nutrition are about lately is where it should come from. Carbs are the only nutrient with a minimum daily intake of zero. Carbs are optional, as to your point, your liver will synthesize all you need to exist or you would be dead. What that process doesn’t come with as much of is a direct spike in insulin and insulin has a lot of downstream effects.
koboll 7y ago
Wouldn't this drug basically enable you to get the same benefits as someone on a low/no-carb diet even if you aren't?
travisp 7y ago
Have you ever checked your blood sugar on a zero carb diet? It’s far from zero. This medication is intended to block glucose transport to cancer cells while not blocking to non-cancer cells. Even if a zero carb diet would be a good idea for a cancer patient in general, there is absolutely no chance that a zero carb diet would be equivalent to the intended mechanism of this medication because people with a zero carb diet still have plenty of glucose.

A carnivorous diet (meat only, zero carbs) would accomplish the same without the pharmacological drawback. Been on the diet for over a year and have never felt better in my life.

toomuchtodo 7y ago

Keto diet is very similar.

justsomeone88 7y ago

Keto/carnivore is incredibly dangerous to the human body in the long run (5+ years out). Excess protein (in fact, even in the amounts society recognizes as "normal") is bad for you. https://www.youtube.com/watch?v=2R07FL1wVo4 https://www.youtube.com/watch?v=2R07FL1wVo4

deleted 7y ago
[deleted]
Mountain_Skies 7y ago
The Vegetarian Society of Hawaii isn't exactly an unbiased source. Maybe for balance we should post a video from the Texas Cattlemen's Association.
- stevespang 7y ago
  Oh yeah, those who murder innocent animals for profit by the hundreds of thousands . . . may they glow in agony in the internal fires of hell
reggintoggaf 7y ago
No it is not.
koboll 7y ago
That video has a lot of pseudoscience ("leaky gut" syndrome, paleo humans never ate meat, etc.) so I'm inclined to distrust it entirely
- Madmallard 7y ago
  Leaky gut pseudoscience :) There's literally thousands of articles on it on pubmed. Paleo humans never ate meat sounds silly, though.
Zelphyr 7y ago
I've been on Keto for almost two years and recently had someone adamantly scold me about how bad it is for my brain. My n=1 suggests otherwise. Things like focus and mood are all significantly better than they were before. Physical and mental stamina have both increased. I went from an "Obese" body fat percentage to "Athletic" in six months. But still, I gave him the benefit of the doubt and sincerely asked him, and ask others here, "Please provide me with studies that show that it's 'horrible for the brain'." I don't mean that to be snarky. I've looked and haven't been able to find the studies. Maybe I've been looking in the wrong places and I would love to read the studies* that show how bad it is. Towards the end of the conversation with this guy I found it amusing that he stopped chiding me long enough to ask, "So... wait, what is Keto?" * Peer-reviewed, scientifically rigorous studies only please.
- mark-r 7y ago
  Maybe your brain function is sufficiently impaired that you can't find the studies? Seriously, I had an accident in March that necessitated a brain operation and left me in the hospital for over a month. The most surprising after-effect is that I can't always predict or recognize the symptoms arising from that.
  - Zelphyr 7y ago
    My dad had a brain operation a few years ago. His recovery has been somewhat slow and wasn't always smooth but it also wasn't as bad as I think we all expected. Brains are mysterious organs. I wish you all the best in your recovery.
- usaphp 7y ago
  > things like focus and mood are all significantly better then before... Was your keto diet the only change in your life? Going from obese to athletic in 6 months probably includes some other good habits like going to gym/physical activity and good sleep etc. So maybe your change in a lifestyle helped you improve you mood and focus, not necessarily the keto diet in particular?
  - 7y ago
i_am_nomad 7y ago
I’m sorry, YouTube is too academic and dense. Could you post a TikTok or a meme with the same info?
- decebalus1 7y ago
  Dear stranger, I was/am having a pretty bad day and then I read your comment and laughed out loud for the first time since yesterday. Thanks!
  - stephenSinniah 7y ago
    Let's save these kind of interactions for reddit, please.

topmonk 7y ago

No, it wouldn't. Your brain needs glucose to survive and your body will manufacture it if it's not present. If you actually were able to accomplish what you're saying, you'd be braindead.

frisco 7y ago
You need ATP. The Krebs cycle can manufacture it from either ketone bodies or from glucose.
- topmonk 7y ago
  You also need glucose. With a blood glucose level of zero, you die.
  - frisco 7y ago
    Again, the important thing is ATP, and you can get it from either glucose or ketone bodies: > In fact, the late George Cahill did an experiment many years ago (probably would never get IRB approval to do such an experiment today) to demonstrate how ketones can offset glucose in the brain. Subjects with very high levels of B-OHB (about 5-7 mM) were injected with insulin until glucose levels reached 1 mM (about 19 mg/dL)! A normal person would fall into a coma at glucose levels below about 40 mg/dL and die by the time blood glucose reached 1 mM. These subjects were completely asymptomatic and 100% neurologically functional. https://peterattiamd.com/ketosis-advantaged-or-misunderstood-state-part-i/ https://peterattiamd.com/ketosis-advantaged-or-misunderstood...
    - maximente 7y ago
      no, you're both oversimplifying. the brain needs some glucose to sustain itself, a little bit, according to present day research. yes, it can principally function on ketones but not /exclusively/. it is not controversial that the brain can survive long periods of time on principally ketones, but what has not yet been proven (for obvious ethical reasons) is whether or not the brain can sustain itself with absolutely no glucose whatsoever. again, the ratios are key. i'm not contesting that ketones can be used as the principal fuel source, just that "the important thing is ATP" because the brain needs some glucose. https://www.ncbi.nlm.nih.gov/books/NBK28048/ https://www.ncbi.nlm.nih.gov/books/NBK28048/

itchyouch 7y ago

with protein only, the protein goes through gluconeogensis and the protein is converted into glucose, whereas in keto, the fat is used as fat...

arcticbull 7y ago
The glycerol backbones in triglycerides also undergo gluconeogenesis.
- tryptophan 7y ago
  Yes. Red blood cells literally can only eat glucose. Without it you would be super dead. I find it amusingly absurd how so many people here seem convinced that our primary food source is somehow a poison. People with 0 carbs in their blood are colloquially known as 'dead'. I wonder if people even know what ketone bodies are... They are a downstream product of glucose processing(also downstream of fats - the inputs are different but the outputs are identical in a few ways), acetyl-coA, stuck together for bloodstream transport with the coenzyme temporarily removed.
  - arcticbull 7y ago
    Glucose is definitely food for humans, I think what the discussions here and more generally in nutrition are about lately is where it should come from. Carbs are the only nutrient with a minimum daily intake of zero. Carbs are optional, as to your point, your liver will synthesize all you need to exist or you would be dead. What that process doesn’t come with as much of is a direct spike in insulin and insulin has a lot of downstream effects.

koboll 7y ago

Wouldn't this drug basically enable you to get the same benefits as someone on a low/no-carb diet even if you aren't?

travisp 7y ago

Have you ever checked your blood sugar on a zero carb diet? It’s far from zero. This medication is intended to block glucose transport to cancer cells while not blocking to non-cancer cells. Even if a zero carb diet would be a good idea for a cancer patient in general, there is absolutely no chance that a zero carb diet would be equivalent to the intended mechanism of this medication because people with a zero carb diet still have plenty of glucose.