I use a catch-all subdomain (like *@something.mydomain.com) that simply forwards to my main account. I then sign up on sites using something like news.ycombinat

I use a catch-all subdomain (like *@something.mydomain.com) that simply forwards to my main account. I then sign up on sites using something like news.ycombinator.com@something.mydomain.com or hackernews@something.mydomain.com. I've been doing it since ~2001. The only downside is long e-mail addresses, but my password manager deals with that for the most part. Subdomain is important, otherwise you get dictionary-style spam email attacks (as well as everything coming to whoever owned the domain before you, if anyone). I've never noticed that style of attack to the sub-domain. I've also got very little actual spam to this. A handful of e-mail addresses were obviously leaked/sold but by far the bulk of the spam I get comes to my primary e-mail address which I never use to sign up for anything.