4 ms·

> By using a “molecular postcode” we have been able to deliver the molecule directly to the mitochondria, the structures that produce energy in cells, where we

by shifto 7y ago

> By using a “molecular postcode” we have been able to deliver the molecule directly to the mitochondria, the structures that produce energy in cells, where we think it acts, allowing us to use tiny doses, which are less likely to cause side effects. Is there more information on this? I want to know when I can expect a pill for this. :)

rasengan 7y ago
Definitely interesting and waiting for the pill as well. Currently, there are a few pills you can take to capture a similar effect (slow down but not reverse): 1. DHEA 2. Niagen 3. CoQ10 YMMV - Please consult a physician before adding any pill/altering diet in your regimen.
- rwmurrayVT 7y ago
  Are these three typically taken in a cocktail or individually?
- echelon 7y ago
  CAUTION I am not a doctor, but I want to caution against blindly taking supplements like this. DEHA is a steroid hormone. These are key components of signalling networks in your body, and they can up or down regulate many different things. It could definitely be pro-cancer [1] Niagen is a precursor to NAD+. Screwing with the NAD+ metabolism might promote cancer [2] There seems to be good concensus on CoQ10. It may not have an associated cancer risk (I couldn't find any literature), but it may lower blood pressure and that should be carefully considered [3] Please do your homework and ask your doctor before taking any of these. There are pros and cons and a whole lot of uncertainties. [1] https://www.mayoclinic.org/drugs-supplements-dhea/art-20364199 https://www.mayoclinic.org/drugs-supplements-dhea/art-203641... [2] https://siteman.wustl.edu/pathway-linked-slower-aging-also-fuels-brain-cancer/ https://siteman.wustl.edu/pathway-linked-slower-aging-also-f... [3] https://www.mayoclinic.org/drugs-supplements-coenzyme-q10/art-20362602 https://www.mayoclinic.org/drugs-supplements-coenzyme-q10/ar...
  - lgats 7y ago
    rasengan posted about DHEA, a compound often found in Fish Oil, not the steroid hormone DEHA.
    - echelon 7y ago
      Sorry, that was a typo. The link I cited is on DHEA. DEHA is an organic compound, not a hormone.
  - LinuxBender 7y ago
    That is why I also cycle up/down Sulforaphane to up-regulate NRF2 and activate several genetic expressions that increase cell autophagy and apoptosis. I also use Berberine (some use metformin) to modify p53. I also take aged garlic extract to break down the biofilm on cancer cells and bio-availability enhanced Curcumin to block metastases or the process. I also do not consume glucose, as cancer cells and tumors require glucose. Operating off Ketones is very beneficial to starving cancer cells. All of that said, based on the studies I have read, the results of CoQ10 only start to become more beneficial at older ages or in people that have had heart damage. It also helps to ensure you are not deficient in potassium and magnesium, as those are very important for mitochondria. Dr. Bruce Ames has done a lot of research in this area and has theories about "conservation" and how various longevity functions in our bodies are muted when we only get the RDA or lower of critical components. I don't have an opinion on NAD+ precursors for humans. Mice studies have produce great results, but it isn't clear yet if NR/NMN help humans AFAIK.
    - shifto 7y ago
      Do you have a starting point for me to read up on this? I'm very interested but this is so far from what I know I didn't even understand half your post. Thanks.
      - LinuxBender 7y ago
        It is a lot of reading. A starting point would be to use google to search for various studies on nih.gov. So in google, use "site:nih.gov topic_of_interest" and don't stop with the first study you find. Some of them are well funded and sometimes for the wrong reasons. I could give a two hour talk on just reading studies on that site. Then after reading everything you can find on each of those topics, you can also watch youtube videos with Dr. Rhonda Patrick and Dr. Bruce Ames on conservation theory. She also talks about sulforaphane at great length. She has a two hour video with another scientist and they go into some of the DoD studies being done with sulforaphane and children in reversing autism. Then for starving cancer cells, both nih.gov and youtube videos by Dr. Eric Berg (DC, not MD) and has spent the last several years researching these topics and making them more consumable by the general population. Dr. Berg sometimes leaves out important pieces of information, so keep reading on any topic he makes youtube videos about.

by shifto 7y ago

rasengan 7y ago

Definitely interesting and waiting for the pill as well. Currently, there are a few pills you can take to capture a similar effect (slow down but not reverse): 1. DHEA 2. Niagen 3. CoQ10 YMMV - Please consult a physician before adding any pill/altering diet in your regimen.

rwmurrayVT 7y ago
Are these three typically taken in a cocktail or individually?
echelon 7y ago
CAUTION I am not a doctor, but I want to caution against blindly taking supplements like this. DEHA is a steroid hormone. These are key components of signalling networks in your body, and they can up or down regulate many different things. It could definitely be pro-cancer [1] Niagen is a precursor to NAD+. Screwing with the NAD+ metabolism might promote cancer [2] There seems to be good concensus on CoQ10. It may not have an associated cancer risk (I couldn't find any literature), but it may lower blood pressure and that should be carefully considered [3] Please do your homework and ask your doctor before taking any of these. There are pros and cons and a whole lot of uncertainties. [1] https://www.mayoclinic.org/drugs-supplements-dhea/art-20364199 https://www.mayoclinic.org/drugs-supplements-dhea/art-203641... [2] https://siteman.wustl.edu/pathway-linked-slower-aging-also-fuels-brain-cancer/ https://siteman.wustl.edu/pathway-linked-slower-aging-also-f... [3] https://www.mayoclinic.org/drugs-supplements-coenzyme-q10/art-20362602 https://www.mayoclinic.org/drugs-supplements-coenzyme-q10/ar...
- lgats 7y ago
  rasengan posted about DHEA, a compound often found in Fish Oil, not the steroid hormone DEHA.
  - echelon 7y ago
    Sorry, that was a typo. The link I cited is on DHEA. DEHA is an organic compound, not a hormone.
- LinuxBender 7y ago
  That is why I also cycle up/down Sulforaphane to up-regulate NRF2 and activate several genetic expressions that increase cell autophagy and apoptosis. I also use Berberine (some use metformin) to modify p53. I also take aged garlic extract to break down the biofilm on cancer cells and bio-availability enhanced Curcumin to block metastases or the process. I also do not consume glucose, as cancer cells and tumors require glucose. Operating off Ketones is very beneficial to starving cancer cells. All of that said, based on the studies I have read, the results of CoQ10 only start to become more beneficial at older ages or in people that have had heart damage. It also helps to ensure you are not deficient in potassium and magnesium, as those are very important for mitochondria. Dr. Bruce Ames has done a lot of research in this area and has theories about "conservation" and how various longevity functions in our bodies are muted when we only get the RDA or lower of critical components. I don't have an opinion on NAD+ precursors for humans. Mice studies have produce great results, but it isn't clear yet if NR/NMN help humans AFAIK.
  - shifto 7y ago
    Do you have a starting point for me to read up on this? I'm very interested but this is so far from what I know I didn't even understand half your post. Thanks.
    - LinuxBender 7y ago
      It is a lot of reading. A starting point would be to use google to search for various studies on nih.gov. So in google, use "site:nih.gov topic_of_interest" and don't stop with the first study you find. Some of them are well funded and sometimes for the wrong reasons. I could give a two hour talk on just reading studies on that site. Then after reading everything you can find on each of those topics, you can also watch youtube videos with Dr. Rhonda Patrick and Dr. Bruce Ames on conservation theory. She also talks about sulforaphane at great length. She has a two hour video with another scientist and they go into some of the DoD studies being done with sulforaphane and children in reversing autism. Then for starving cancer cells, both nih.gov and youtube videos by Dr. Eric Berg (DC, not MD) and has spent the last several years researching these topics and making them more consumable by the general population. Dr. Berg sometimes leaves out important pieces of information, so keep reading on any topic he makes youtube videos about.