At least in the context of toenail fungus, the topical treatments avoid risk to your liver (but generally don't work because it's hard to penetrate the nail and

At least in the context of toenail fungus, the topical treatments avoid risk to your liver (but generally don't work because it's hard to penetrate the nail and nail bed). However, even assuming a carcinogenic role for fungus, topical treatments are very unlikely to be useful for preventing internal cancers like pancreatic cancer.