I am not sure if interfering is appropriate here. Even in the current state, usually, browser perform DNS queries directly with DNS server, that they take from

I am not sure if interfering is appropriate here. Even in the current state, usually, browser perform DNS queries directly with DNS server, that they take from DHCP, which in it's turn supplied to the router by ISP. This has nothing to do with other web clients or IoT performing DNS lookups. The question is whether Chrome is going to ignore system settings by default.