4 ms·
Wasn't the amyloid-plaque etiology debunked recently?
by AlexCoventry 7y ago
Wasn't the amyloid-plaque etiology debunked recently?
- anonuser123456 7y agoNot debunked, just very much in question. A number of amyloid clearing drug trails have failed to achieve clinical progress on the disease in spite of clearing beta-amyloid.
- jcranmer 7y agoI'll let Derek Lowe (of Things I Won't Work With/In the Pipeline fame) summarize it: https://blogs.sciencemag.org/pipeline/archives/2019/03/21/a-brief-note-about-alzheimers https://blogs.sciencemag.org/pipeline/archives/2019/03/21/a-... > Something is wrong with the way we’re thinking about Alzheimer’s and amyloid, folks, something is wrong. It’s been wrong for a long time and that’s been clear for a long time. Do something else.
- lonelappde 7y agoFrom that summary it seems that amyloid may be an effect, not a cause, of Alzheimer's.