I mean, people have tried several promising new Alzheimer's medications which failed, along with a host of snake oil nonsense. I'd have to go and dig up studie

I mean, people have tried several promising new Alzheimer's medications which failed, along with a host of snake oil nonsense. I'd have to go and dig up studies, but my memory is that even the control groups don't see particularly good results; neurodegenerative disorders are just too fundamental. Most of the promising results for brain activity and dementia seem to represent either keeping information "active" so that it's not consolidated away by normal aging, or keeping patients engaged so that they have better cognitive performance despite unchecked biological losses. I agree that if this only saw improvement on cognitive scores, a placebo delaying decline would be pretty concerning. But the biological improvements are better than drug or placebo for any other Alzheimer's medicine I've seen, which is very promising.