3 ms·

Got a reference for ioannidis on this topic specifically?

by rmtech 7y ago

jeremyw 7y ago
Sure, start with these. Good references, too. Perspective: Limiting Dependence on Nonrandomized Studies and Improving Randomized Trials in Human Nutrition Research: Why and How https://academic.oup.com/advances/article/9/4/367/5055939 https://academic.oup.com/advances/article/9/4/367/5055939 Implausible results in human nutrition research https://www.bmj.com/content/347/bmj.f6698 https://www.bmj.com/content/347/bmj.f6698 His most famous paper, Why Most Published Research Findings Are False https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... Here's a talk on nutrition science methods, along with a specific audience moment with Walter Willet, former head of Harvard Nutrition dept, and advocate for his questionnaires. https://www.youtube.com/watch?v=KTAbx4i8Dyg https://www.youtube.com/watch?v=KTAbx4i8Dyg -- https://youtu.be/KTAbx4i8Dyg?t=23m40s https://youtu.be/KTAbx4i8Dyg?t=23m40s
- o09rdk 7y ago
  After reading the BMJ piece I wondered if any study strategy would satisfy Ioannidis, to be honest. I came away from it feeling like his calls to eliminate observational studies and smaller randomized trials are misleading in that he seems to believe that all realistic studies should be eliminated. He seems to be in favor of large randomized-controlled comprehensive diet protocols, for example, where many aspects of diets are manipulated simultaneously. He dismisses them too, though, for very good reasons. Given that there were additional reasons to be skeptical of such studies he didn't mention, I was left wondering if his pleas for study designs should be heeded very much (as opposed to his criticism of specific flaws). I love his work, but am wondering if it's best approached as worst-case criticism rather than an inspiration for what to do.
  - jeremyw 7y ago
    That's interesting. I read him (in total) as being quite optimistic about the way forward, if intertia and self-interest can be overcome. He's listed as an author in a number of nutritional and other studies. One might see those as leaning in his direction, if he's willing to be mentioned. You might contact him if you have additional doubts.

Got a reference for ioannidis on this topic specifically?

by rmtech 7y ago

Got a reference for ioannidis on this topic specifically?

Sure, start with these. Good references, too. Perspective: Limiting Dependence on Nonrandomized Studies and Improving Randomized Trials in Human Nutrition Research: Why and How https://academic.oup.com/advances/article/9/4/367/5055939 https://academic.oup.com/advances/article/9/4/367/5055939 Implausible results in human nutrition research https://www.bmj.com/content/347/bmj.f6698 https://www.bmj.com/content/347/bmj.f6698 His most famous paper, Why Most Published Research Findings Are False https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... Here's a talk on nutrition science methods, along with a specific audience moment with Walter Willet, former head of Harvard Nutrition dept, and advocate for his questionnaires. https://www.youtube.com/watch?v=KTAbx4i8Dyg https://www.youtube.com/watch?v=KTAbx4i8Dyg -- https://youtu.be/KTAbx4i8Dyg?t=23m40s https://youtu.be/KTAbx4i8Dyg?t=23m40s

o09rdk 7y ago
After reading the BMJ piece I wondered if any study strategy would satisfy Ioannidis, to be honest. I came away from it feeling like his calls to eliminate observational studies and smaller randomized trials are misleading in that he seems to believe that all realistic studies should be eliminated. He seems to be in favor of large randomized-controlled comprehensive diet protocols, for example, where many aspects of diets are manipulated simultaneously. He dismisses them too, though, for very good reasons. Given that there were additional reasons to be skeptical of such studies he didn't mention, I was left wondering if his pleas for study designs should be heeded very much (as opposed to his criticism of specific flaws). I love his work, but am wondering if it's best approached as worst-case criticism rather than an inspiration for what to do.
- jeremyw 7y ago
  That's interesting. I read him (in total) as being quite optimistic about the way forward, if intertia and self-interest can be overcome. He's listed as an author in a number of nutritional and other studies. One might see those as leaning in his direction, if he's willing to be mentioned. You might contact him if you have additional doubts.