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It's complicated. Telling people who have been abstaining from eating red meat that it's ok to eat it might also be a bad idea. Humans lost the enzyme that con

It's complicated. Telling people who have been abstaining from eating red meat that it's ok to eat it might also be a bad idea. Humans lost the enzyme that converts Neu5Ac to Neu5Gc. Other animals have Neu5Gc, which can be incorporated into your own tissues and potentially be recognized as foreign. So if you haven't been exposed to animal products and you suddenly are, that could trigger auto-immunity. Oh and of course, the gut microbiota has a role in regulating all of this. (https://www.nature.com/articles/s41564-019-0564-9 https://www.nature.com/articles/s41564-019-0564-9)

tathougies 7y ago
As an anecdote, my wife gave up vegetarianism after ten years and suffered no consequences coming back onto meat. She started with a tiny bit of pork and the next day was eating chicken, pork, etc. The fact is humans are omnivores.
- pazimzadeh 7y ago
  That makes sense - by starting with small amounts you're more likely to induce oral tolerance. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603531/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603531/
- deleted 7y ago
  [deleted]
- geggam 7y ago
  My wife tried every diet known, when she started eating Keto style and even strict carnivorous all of her stomach issues went away. Just from observing her and the kids I think there are huge benefits to not eating carbohydrates. Some of this benefit could be related to the chemicals in the foods but every time she eats any grains or grain products she gets stomach issues I dont have any stomach issues except I gain weight when I eat carbs. No carbs and the weight goes off. There is more to this issue than meat vs grains IMO BTW... does anyone have a reference to a medical study showing why the US recommended diet is recommended ?
  - ssijak 7y ago
    Anegdotal evidence are just that, anecdotal. Most of the studies show that all the unprocessed complex and fibrous carbohidrates are very good for health, but eating spoons of sugar is obviously bad. All the longevity experts that I listened to and read what they say also agree that in general protein should be at a very slight nitrogen positive balance (so less then 100g per day for most of people) and rest is carbs and some fats. And yes, not everyone i
    - amanaplanacanal 7y ago
      Unfortunately the state of the science is such that finding what works best for you yourself is about the best we can do. I'm certain there are some folks that do best strict carnivore, and some others that do best strict vegan, and everywhere in between.
  - noelsusman 7y ago
    Warning, very large pdf: https://health.gov/dietaryguidelines/2015-scientific-report/PDFs/Scientific-Report-of-the-2015-Dietary-Guidelines-Advisory-Committee.pdf https://health.gov/dietaryguidelines/2015-scientific-report/...
01100011 7y ago
It's my understanding that Neu5Gc can trigger a low-level inflammatory response, but generally not auto-immune disease as it is typically defined. It may be that the resulting inflammation is less damaging than inflammation caused by things like increased carbohydrate or omega-6 oil intake.
lhl 7y ago
For those not clicking through on the paper (it came up in discussion in one of my metabolomics groups the other day) the paper you cited shows that (previously unknown) that there would be microbiome adaptations that could mitigate previously theorized issues with meat consumption: "We found that a Neu5Gc-rich diet induces changes in the gut microbiota, with Bacteroidales and Clostridiales responding the most. ... Additionally, we verified that mouse and human sialidases were able to release Neu5Gc from red meat. The release of Neu5Gc from red meat using bacterial sialidases could reduce the risk of inflammatory diseases associated with red meat consumption, including colorectal cancer and atherosclerosis." The human microbiome is very diverse and adaptable. It seems to be good at processing just about any evolutionarily available (eg, non ultra-processed) foods you give it: https://www.nature.com/articles/ismej2011212 https://www.nature.com/articles/ismej2011212

tathougies 7y ago

As an anecdote, my wife gave up vegetarianism after ten years and suffered no consequences coming back onto meat. She started with a tiny bit of pork and the next day was eating chicken, pork, etc. The fact is humans are omnivores.

pazimzadeh 7y ago
That makes sense - by starting with small amounts you're more likely to induce oral tolerance. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603531/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603531/
deleted 7y ago
[deleted]
geggam 7y ago
My wife tried every diet known, when she started eating Keto style and even strict carnivorous all of her stomach issues went away. Just from observing her and the kids I think there are huge benefits to not eating carbohydrates. Some of this benefit could be related to the chemicals in the foods but every time she eats any grains or grain products she gets stomach issues I dont have any stomach issues except I gain weight when I eat carbs. No carbs and the weight goes off. There is more to this issue than meat vs grains IMO BTW... does anyone have a reference to a medical study showing why the US recommended diet is recommended ?
- ssijak 7y ago
  Anegdotal evidence are just that, anecdotal. Most of the studies show that all the unprocessed complex and fibrous carbohidrates are very good for health, but eating spoons of sugar is obviously bad. All the longevity experts that I listened to and read what they say also agree that in general protein should be at a very slight nitrogen positive balance (so less then 100g per day for most of people) and rest is carbs and some fats. And yes, not everyone i
  - amanaplanacanal 7y ago
    Unfortunately the state of the science is such that finding what works best for you yourself is about the best we can do. I'm certain there are some folks that do best strict carnivore, and some others that do best strict vegan, and everywhere in between.
- noelsusman 7y ago
  Warning, very large pdf: https://health.gov/dietaryguidelines/2015-scientific-report/PDFs/Scientific-Report-of-the-2015-Dietary-Guidelines-Advisory-Committee.pdf https://health.gov/dietaryguidelines/2015-scientific-report/...

01100011 7y ago

It's my understanding that Neu5Gc can trigger a low-level inflammatory response, but generally not auto-immune disease as it is typically defined. It may be that the resulting inflammation is less damaging than inflammation caused by things like increased carbohydrate or omega-6 oil intake.

lhl 7y ago

For those not clicking through on the paper (it came up in discussion in one of my metabolomics groups the other day) the paper you cited shows that (previously unknown) that there would be microbiome adaptations that could mitigate previously theorized issues with meat consumption: "We found that a Neu5Gc-rich diet induces changes in the gut microbiota, with Bacteroidales and Clostridiales responding the most. ... Additionally, we verified that mouse and human sialidases were able to release Neu5Gc from red meat. The release of Neu5Gc from red meat using bacterial sialidases could reduce the risk of inflammatory diseases associated with red meat consumption, including colorectal cancer and atherosclerosis." The human microbiome is very diverse and adaptable. It seems to be good at processing just about any evolutionarily available (eg, non ultra-processed) foods you give it: https://www.nature.com/articles/ismej2011212 https://www.nature.com/articles/ismej2011212