3 ms·
I wonder why it took the medical profession so long to become aware of the effect. Piperonyl butoxide, another cytochrome C inhibitor, has been used as synergis
by HarryHirsch 7y ago
I wonder why it took the medical profession so long to become aware of the effect. Piperonyl butoxide, another cytochrome C inhibitor, has been used as synergist in insecticides since before the war, so it should have occurred to someone that the plentiful polyphenols in citrus juice could act as cytochrome C inducers/inhibitors and would have a measurable influence on the pharmacokinetics of stuff.
- arkades 7y agoJust because the article says that the healthcare community is ignorant of it, doesn’t mean that it’s ignorant of it. We had to memorize major CYP4503A4 inducers and inhibitors for step exams back when I was in med school, and memorized metabolic pathways and involved cytochromes for most major drugs. Granted, most docs don’t remember all the details long out of med school (because that’s literally what pharmacists are -for-), but we retain the broad brushstrokes. Ain’t new. Just editorializing bs.
- p1necone 7y agoYeah, hasn't "don't eat grapefruit while on birth control" been common advice for years?
- KineticLensman 7y agoYes, also on medication for high-blood pressure. (luckily I never had a great liking for grapefruit)
- helpPeople 7y agoCommon advice? Whos job is it to teach this?
- guscost 7y agoI think “the war” refers to World War II (curious name for it!) and this person still has a point, unless you went to med school before 1990. The wiki[0] says that the effect was discovered in 1989, and lots of the referenced literature is from 2002/2003. [0] https://en.m.wikipedia.org/wiki/Grapefruit–drug_interactions https://en.m.wikipedia.org/wiki/Grapefruit–drug_interactions
- bgeeek 7y agoIt's quite normal here to refer to it as the war. "Back in the war..." :)
- Wistar 7y agoI distinctly remember being told to avoid grapefruit with certain antibiotics in the early 90s. I know that, in about 2000, my father was told to avoid grapefruit all the time because he was taking drugs for gout. He loved grapefruit and complained bitterly about the restriction.