I might have expected colchicine (https://en.wikipedia.org/wiki/Colchicine https://en.wikipedia.org/wiki/Colchicine) to be on the list. It's a fairly harsh dru

I might have expected colchicine (https://en.wikipedia.org/wiki/Colchicine https://en.wikipedia.org/wiki/Colchicine) to be on the list. It's a fairly harsh drug with a narrow therapeutic window. Getting the right dosage is already hard enough, as there are some unpleasant (and common) side effects, and it can also be pretty dangerous to your health. Add something like grapefruit that throws off the concentration, and things get that much worse. EDIT: This HN story link was updated. The list I was referring to above is the old link: https://en.wikipedia.org/wiki/Grapefruit–drug_interactions https://en.wikipedia.org/wiki/Grapefruit–drug_interactions