3 ms·
Sickle cell anemia is Mendelian and recessive. So if 2 carriers (Rr and Rr) have kids, 50% of the children will be strictly superior (carriers), 25% will be nor
by mruts 7y ago
Sickle cell anemia is Mendelian and recessive. So if 2 carriers (Rr and Rr) have kids, 50% of the children will be strictly superior (carriers), 25% will be normal, and 25% will die young. Not a bad outcome, especially if you have a lot of kids to reduce the variance.
- kbenson 7y ago> 50% of the children will be strictly superior (carriers) Is that domain nomenclature? Because I wouldn't call having to be careful who procreate with otherwise risk losing 25% of my children from that relationship as "strictly superior"...
- rangibaby 7y ago2/4 resistant to malaria with no side effects and 1/4 dying is much much better than 4/4 dying from malaria
- wespiser_2018 7y agopretty good considering something like half of all human beings who ever lived died of Malaria!
- lazyasciiart 7y agoI am mildly disappointed to learn that this is probably an overestimate, although it is pretty significant http://factmyth.com/factoids/malaria-killed-half-the-people-who-have-ever-lived/ http://factmyth.com/factoids/malaria-killed-half-the-people-...
- wespiser_2018 7y agoThanks for calling it out! I think I first heard this from Plasmodium researchers, and in my mind the claim has strengthen over time. A better statement would be: "“Malaria could have potentially killed nearly to half the people who ever lived, predominantly children”." And this is based off the idea that for most of human history people have lived in Sub-Saharan Africa, where the majority of people who lived died as children, and the predominate cause of death was Malaria.