Evidence is still inconclusive on a lot of things, but my list is: #1. Keep your mind active as much as possible. Waste time by working puzzles instead of rea

Evidence is still inconclusive on a lot of things, but my list is: #1. Keep your mind active as much as possible. Waste time by working puzzles instead of reading People magazine. Constantly learn new things whether they're useful or not, both inside and outside your domain of expertise. This approach has the most proven benefits and no known drawbacks. #2. Lean toward a Mediterranean diet and drink a glass of red wine every evening. I don't think there's any need to be anal about it, but just avoid Atkins-like diets, take the fish option if one is available, etc. #3. Stay physically active as much as possible. If you live in a walkable neighborhood, you're halfway there with no effort. #4. Drink up to a cup of coffee a day. Also strongly implicated in improving prostate and kidney health, but may have cardiovascular disadvantages. #5. Take B vitamins. I started with the widely-available "B-50" complex and moved up to "B-100" with an additional folate supplement to get to a total of 200% US RDA of folate. Evidence is sketchy about long-term benefits, but I find the effect to be similar to a cup of coffee without the crash or the jitters, so I'm sticking with it for that reason alone.