3 ms·

That’s cool that it works well , but aren’t there trade-offs for everything? This method seems to help your brain work more because it increases its metabolism

by vntx 7y ago

That’s cool that it works well , but aren’t there trade-offs for everything? This method seems to help your brain work more because it increases its metabolism but that might also cause your brain to age faster right? The harder you work something, the faster you wear it down. Is my logic flawed or am I missing something? Just curious.

rubicon33 7y ago
This is a good point and I think it's a safe assumption that you're right, but here's another tid bit to consider: Perhaps some people have abnormally SLOW brain aging / metabolism. This would be a way for them to get back to normal?
manmal 7y ago
Photobiomodulation does not work cells/mitochondria harder, but on the contrary, it releases nitric oxide from cells which is a by-product of oxidate stress. The immediate positive effects are probably from vasodilation, which increases blood flow to tissue, and increased ATP production via the cytochrome C oxidase pathway. Longer term beneficial effects might stem from increased stem cell proliferation and suppression of inflammation (inflammation is highly suspected to be based on a lack of energy in cells, so it makes sense that increasing ATP production helps in that area). Here is a study where near infrared light actually increased lifespan for fruit flies: Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation. Near-infrared exposure increases retinal ATP in old mice via cytochrome c oxidase absorption and reduces inflammation. Here, we expose fruitflies daily to 670 nm radiation, revealing elevated ATP and reduced inflammation with age. Critically, there was a significant increase in average lifespan: 100–175% more flies survived into old age following 670 nm exposure and these had significantly improved mobility. This may be a simple route to extending lifespan and improving function in old age. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387504/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387504/

by vntx 7y ago

rubicon33 7y ago

This is a good point and I think it's a safe assumption that you're right, but here's another tid bit to consider: Perhaps some people have abnormally SLOW brain aging / metabolism. This would be a way for them to get back to normal?

manmal 7y ago

Photobiomodulation does not work cells/mitochondria harder, but on the contrary, it releases nitric oxide from cells which is a by-product of oxidate stress. The immediate positive effects are probably from vasodilation, which increases blood flow to tissue, and increased ATP production via the cytochrome C oxidase pathway. Longer term beneficial effects might stem from increased stem cell proliferation and suppression of inflammation (inflammation is highly suspected to be based on a lack of energy in cells, so it makes sense that increasing ATP production helps in that area). Here is a study where near infrared light actually increased lifespan for fruit flies: Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation. Near-infrared exposure increases retinal ATP in old mice via cytochrome c oxidase absorption and reduces inflammation. Here, we expose fruitflies daily to 670 nm radiation, revealing elevated ATP and reduced inflammation with age. Critically, there was a significant increase in average lifespan: 100–175% more flies survived into old age following 670 nm exposure and these had significantly improved mobility. This may be a simple route to extending lifespan and improving function in old age. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387504/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387504/