4 ms·

I love the phrase metabolic derangements. It accurately conveys how completely abnormal the changes are.

SketchySeaBeast 7y ago
It seems melodramatic to me. And these abnormal changes can be mitigated by walking those 10,000 steps a day they reduced their activity by. That requires a conscious effort, but it's not an onerous burden.
- ska 7y ago
  It is not melodramatic, it is a technical term being used properly. You are perhaps thinking about the psychiatric usage implying a significant mental disorder, but here it just means that the system (i.e. metabolism) has been disturbed in its function, e.g. that it is out of normal range.
  - SketchySeaBeast 7y ago
    Pendantically yes, and yes, it describes the problem, and used medically it's not melodramatic, but looking at the original comments text: > It accurately conveys how completely abnormal the changes are. that would make no sense in the medically accurate context. Derangement being used as "something disturbed in its function" is literally anything being wrong, no matter how minor. It doesn't have to be "completely abnormal", merely abnormal by some means. The post I was responding too clearly doesn't believe it to be a minor dysfunction and wasn't understanding it in the technical context either.
    - JohnJamesRambo 7y ago
      It's not a minor dysfunction. >Pooling data from both groups, following step reduction there was a significant decrease in whole-body insulin sensitivity (Matsuda index) (p < 0.001), muscle insulin sensitivity index (p < 0.001), cardiorespiratory fitness (p = 0.002) and lower limb lean mass (p = 0.004). Further, there was a significant increase in total body fat (p < 0.001), liver fat (p = 0.001) and LDL-cholesterol (p = 0.013), with a borderline significant increase in NEFA AUC during the OGTT (p = 0.050). Those are incredible p values to find in a human study.
      - SketchySeaBeast 7y ago
        But, as I original pointed out, it's mitigated by maintaining a non-extreme level of activity - throwing on ~10,000 steps is the difference here.
        ska 7y ago
        The fact that the fix is relatively easy is not really a measure of how far off things are - some pretty terrible disorders have easy fixes...
        AstralStorm 7y ago
        I wonder how it reacts to walking on stairs. Less steps, more, or the same?

It seems melodramatic to me. And these abnormal changes can be mitigated by walking those 10,000 steps a day they reduced their activity by. That requires a conscious effort, but it's not an onerous burden.

ska 7y ago
It is not melodramatic, it is a technical term being used properly. You are perhaps thinking about the psychiatric usage implying a significant mental disorder, but here it just means that the system (i.e. metabolism) has been disturbed in its function, e.g. that it is out of normal range.
- SketchySeaBeast 7y ago
  Pendantically yes, and yes, it describes the problem, and used medically it's not melodramatic, but looking at the original comments text: > It accurately conveys how completely abnormal the changes are. that would make no sense in the medically accurate context. Derangement being used as "something disturbed in its function" is literally anything being wrong, no matter how minor. It doesn't have to be "completely abnormal", merely abnormal by some means. The post I was responding too clearly doesn't believe it to be a minor dysfunction and wasn't understanding it in the technical context either.
  - JohnJamesRambo 7y ago
    It's not a minor dysfunction. >Pooling data from both groups, following step reduction there was a significant decrease in whole-body insulin sensitivity (Matsuda index) (p < 0.001), muscle insulin sensitivity index (p < 0.001), cardiorespiratory fitness (p = 0.002) and lower limb lean mass (p = 0.004). Further, there was a significant increase in total body fat (p < 0.001), liver fat (p = 0.001) and LDL-cholesterol (p = 0.013), with a borderline significant increase in NEFA AUC during the OGTT (p = 0.050). Those are incredible p values to find in a human study.
    - SketchySeaBeast 7y ago
      But, as I original pointed out, it's mitigated by maintaining a non-extreme level of activity - throwing on ~10,000 steps is the difference here.
      - ska 7y ago
        The fact that the fix is relatively easy is not really a measure of how far off things are - some pretty terrible disorders have easy fixes...
      - AstralStorm 7y ago
        I wonder how it reacts to walking on stairs. Less steps, more, or the same?