Not to disagree (this is the second Little Alchemy after all) just to add a more original original: Christian Steinruecken's DOS game "Alchemy" from 1997. Which

Not to disagree (this is the second Little Alchemy after all) just to add a more original original: Christian Steinruecken's DOS game "Alchemy" from 1997. Which also inspired a mobile "Alchemy" from 2010 and the incredibly popular "Doodle God" and "Little Alchemy". But kudos to Christian for the original game (or at least, the first one I have come across).