Has anyone experienced more frequent RSI or carpal tunnel syndrome (or any hand pain) as a result of using the larger iPhones? It might just be me, but ever sin

Has anyone experienced more frequent RSI or carpal tunnel syndrome (or any hand pain) as a result of using the larger iPhones? It might just be me, but ever since I transitioned from the old iPhone 4's to the iPhone Plus', I have had more instances of random hand-related pain.