5 ms·

MSI-1436 stimulates regeneration of heart and multiple other tissues

116 points by nirmalc 7y ago

AstralStorm 7y ago
Hopefully this works too in Phase 2 and Phase 3 trials. Looks promising. And doesn't get patented to hell with insane pricing.
- rootw0rm 7y ago
  patents don't mean shit. if it's safe, effective, and profitable I'll be able to custom order it soon enough.
  - brian_herman__ 7y ago
    How and where do you do this?!
    - rootw0rm 7y ago
      labs in India and China.
      - missosoup 7y ago
        India has been pretty open and vocal about ignoring pharma patents when it comes to medications. They put the needs of the people above the financial wants of the industry. It's been a cause of tension in trade negotiations.
        ganeshkrishnan 7y ago
        Please. It's not ignoring patents. It's about ignoring patents after time limit and not allowing patents with minor modifications. Insulin is still patented in US even though it was invented in Canada.
        missosoup 7y ago
        > Please. It's not ignoring patents. Yes it is. And the pharma industry is pretty butthurt about it. https://blogs.wsj.com/indiarealtime/2015/03/19/inside-india-indias-fight-against-big-pharma-patents-is-a-just-war/ https://blogs.wsj.com/indiarealtime/2015/03/19/inside-india-... https://www.forbes.com/sites/johnlamattina/2013/04/08/indias-solution-to-drug-costs-ignore-patents-and-control-prices-except-for-home-grown-drugs/#162804722cba https://www.forbes.com/sites/johnlamattina/2013/04/08/indias...
        ganeshkrishnan 7y ago
        It says in the article >India’s law sets a higher bar for protection than in some other countries, limiting the ability of companies to get patents for new versions of drugs whose active ingredients were previously known unless they can show significant therapeutic benefit. It's not ignoring patents, it's setting a high bar for them. You can't rehash old medicine and patent them.
        gingabriska 7y ago
        >India has been pretty open and vocal about ignoring pharma patents when it comes to medications. They put the needs of the people above the financial wants of the industry. US doesn't put as much pressure because India used "Bhopal Gas Plant Tradegy" for negotiation. If US really wanted to enforce anything, they could have simply banned outsourcing to India. There is lots of damage US can do to India on that front, they don't care enough for now for it to matter.
  - jokowueu 7y ago
    Dep nding on how complex the molecule is sometimes they won't even be able to make it . More than the half the group buys on that specific longevity forum failed
    - rootw0rm 7y ago
      that's absolutely true, i can't deny that. my experience is mostly with cathinones, phenethylamines, and a few substituted amphetamines. oh, and some tryptamines.
      - therein 7y ago
        I remember getting NSI-189 synthesized by a Polish lab back in the day. An interesting time of my life.
        DrAwdeOccarim 7y ago
        Fascinating chemical. Looks like you can buy it around a lot of places now-a-days. Did you notice any benefits from a nootropic standpoint?
        jokowueu 7y ago
        I was there during it . There were 2 forms the freebase and the phosphate form . The phosphate form is what was being used in the phase trials . Many found huge beneficial results but it seemed like all of it was plocebo . It failed phase 2 trials and the company's sticks were in free fall . I knew something was up when thr CEO (iirc) sold most of his stocks before they released the data.
        therein 7y ago
        This is all anecdotal so probably not enough to be conclusive but I've noticed both a somewhat nootropic but definitely a significantly mood-enhancing effect from it. Color were brighter after the first few days. Not psychedelic brighter but bluer blues, greener greens. What I felt was reminiscent of that child-like awe in experiences along with remembering instances of those awe-filled moments I had as a child. Looking at the sky and watching the nature (which is something I hadn't been doing in years) made think "I'm lucky to be able to observe this". Looking at the sky and watching the way clouds move brought back flashbacks of probably the last time I had done that as a kid. Very interesting chemical indeed. I believe it has a lot of potential. After using up my supply, there was no withdrawal or crash. I guess the color enhancement went away gradually over a few months. However I could argue I got permanent memory enhancement from it. I have no data to support it but I became the kind of person that can remember the most obscure things and follow really long chains of connotations. And if you asked me, I wasn't like that before experimenting with NSI-189. But that being said, I even tried Cerebrolysin months before that for nootropic exploration. So for all we know, the memory enhancement stems from that. In hindsight, I must have been very daring to have injected myself with peptides purified from pig brains. :)
  - jksmith 7y ago
    Yep, looking into it.
jz_ 7y ago
The latest news on the compound is from April 2019: https://www.eurekalert.org/pub_releases/2019-04/nb-nba041019.php https://www.eurekalert.org/pub_releases/2019-04/nb-nba041019... If anyone is interested in a talk by one of the authors (Kevin Strange), he goes into the history of the compound here: https://www.youtube.com/watch?v=6aAr5pKW9Dw https://www.youtube.com/watch?v=6aAr5pKW9Dw For progress on similar lines of tech, this is a good site: https://www.lifespan.io/the-rejuvenation-roadmap/ https://www.lifespan.io/the-rejuvenation-roadmap/
bitwize 7y ago
...in zebrafish. Settle down, the answer to all your health problems is still fasting.
- Numberwang 7y ago
  Thank you for curing my aidscancer
- chrisco255 7y ago
  "It is particularly noteworthy that MSI-1436 stimulates tissue regeneration in both zebrafish and adult mice, two widely divergent species that are separated by approximately 450 million years of evolution." Also paper explained that the drug had been applied in Phase 1 clinical trials with humans as a treatment for diabetes and obesity. "Importantly, the doses we have shown to be effective in stimulating tissue regeneration are 5–50-times lower than the maximum well-tolerated human dose."
- taneq 7y ago
  Wait till the mice hear about this one!
aussieguy1234 7y ago
Zebrafish != Humans
- sheeshkebab 7y ago
  It passed phase 1 trial in humans as well.
samairr8 7y ago
msi company is very good thanks for sharing][/url] [url=https://www.coinhashreports.com/2019/03/best-free-monero-cloud-mining-in-2019.html]free https://www.coinhashreports.com/2019/03/best-free-monero-clo... monero cloud mining[/url]
ur-whale 7y ago
Legitimate question : how hard would it be to synthesize in one's garage?
kirykl 7y ago
I wonder how this would affect patients whom have had cardiac ablation, possibly causing unwanted cellular re-growth
defterGoose 7y ago
ITT: People who read nothing past the first paragraph saying, 'Yeah, but only in zebrafish ppl'

116 points by nirmalc 7y ago

Hopefully this works too in Phase 2 and Phase 3 trials. Looks promising. And doesn't get patented to hell with insane pricing.

rootw0rm 7y ago
patents don't mean shit. if it's safe, effective, and profitable I'll be able to custom order it soon enough.
- brian_herman__ 7y ago
  How and where do you do this?!
  - rootw0rm 7y ago
    labs in India and China.
    - missosoup 7y ago
      India has been pretty open and vocal about ignoring pharma patents when it comes to medications. They put the needs of the people above the financial wants of the industry. It's been a cause of tension in trade negotiations.
      - ganeshkrishnan 7y ago
        Please. It's not ignoring patents. It's about ignoring patents after time limit and not allowing patents with minor modifications. Insulin is still patented in US even though it was invented in Canada.
        missosoup 7y ago
        > Please. It's not ignoring patents. Yes it is. And the pharma industry is pretty butthurt about it. https://blogs.wsj.com/indiarealtime/2015/03/19/inside-india-indias-fight-against-big-pharma-patents-is-a-just-war/ https://blogs.wsj.com/indiarealtime/2015/03/19/inside-india-... https://www.forbes.com/sites/johnlamattina/2013/04/08/indias-solution-to-drug-costs-ignore-patents-and-control-prices-except-for-home-grown-drugs/#162804722cba https://www.forbes.com/sites/johnlamattina/2013/04/08/indias...
        ganeshkrishnan 7y ago
        It says in the article >India’s law sets a higher bar for protection than in some other countries, limiting the ability of companies to get patents for new versions of drugs whose active ingredients were previously known unless they can show significant therapeutic benefit. It's not ignoring patents, it's setting a high bar for them. You can't rehash old medicine and patent them.
      - gingabriska 7y ago
        >India has been pretty open and vocal about ignoring pharma patents when it comes to medications. They put the needs of the people above the financial wants of the industry. US doesn't put as much pressure because India used "Bhopal Gas Plant Tradegy" for negotiation. If US really wanted to enforce anything, they could have simply banned outsourcing to India. There is lots of damage US can do to India on that front, they don't care enough for now for it to matter.
- jokowueu 7y ago
  Dep nding on how complex the molecule is sometimes they won't even be able to make it . More than the half the group buys on that specific longevity forum failed
  - rootw0rm 7y ago
    that's absolutely true, i can't deny that. my experience is mostly with cathinones, phenethylamines, and a few substituted amphetamines. oh, and some tryptamines.
    - therein 7y ago
      I remember getting NSI-189 synthesized by a Polish lab back in the day. An interesting time of my life.
      - DrAwdeOccarim 7y ago
        Fascinating chemical. Looks like you can buy it around a lot of places now-a-days. Did you notice any benefits from a nootropic standpoint?
        jokowueu 7y ago
        I was there during it . There were 2 forms the freebase and the phosphate form . The phosphate form is what was being used in the phase trials . Many found huge beneficial results but it seemed like all of it was plocebo . It failed phase 2 trials and the company's sticks were in free fall . I knew something was up when thr CEO (iirc) sold most of his stocks before they released the data.
        therein 7y ago
        This is all anecdotal so probably not enough to be conclusive but I've noticed both a somewhat nootropic but definitely a significantly mood-enhancing effect from it. Color were brighter after the first few days. Not psychedelic brighter but bluer blues, greener greens. What I felt was reminiscent of that child-like awe in experiences along with remembering instances of those awe-filled moments I had as a child. Looking at the sky and watching the nature (which is something I hadn't been doing in years) made think "I'm lucky to be able to observe this". Looking at the sky and watching the way clouds move brought back flashbacks of probably the last time I had done that as a kid. Very interesting chemical indeed. I believe it has a lot of potential. After using up my supply, there was no withdrawal or crash. I guess the color enhancement went away gradually over a few months. However I could argue I got permanent memory enhancement from it. I have no data to support it but I became the kind of person that can remember the most obscure things and follow really long chains of connotations. And if you asked me, I wasn't like that before experimenting with NSI-189. But that being said, I even tried Cerebrolysin months before that for nootropic exploration. So for all we know, the memory enhancement stems from that. In hindsight, I must have been very daring to have injected myself with peptides purified from pig brains. :)
- jksmith 7y ago
  Yep, looking into it.

jz_ 7y ago

The latest news on the compound is from April 2019: https://www.eurekalert.org/pub_releases/2019-04/nb-nba041019.php https://www.eurekalert.org/pub_releases/2019-04/nb-nba041019... If anyone is interested in a talk by one of the authors (Kevin Strange), he goes into the history of the compound here: https://www.youtube.com/watch?v=6aAr5pKW9Dw https://www.youtube.com/watch?v=6aAr5pKW9Dw For progress on similar lines of tech, this is a good site: https://www.lifespan.io/the-rejuvenation-roadmap/ https://www.lifespan.io/the-rejuvenation-roadmap/

bitwize 7y ago

...in zebrafish. Settle down, the answer to all your health problems is still fasting.

Numberwang 7y ago
Thank you for curing my aidscancer
chrisco255 7y ago
"It is particularly noteworthy that MSI-1436 stimulates tissue regeneration in both zebrafish and adult mice, two widely divergent species that are separated by approximately 450 million years of evolution." Also paper explained that the drug had been applied in Phase 1 clinical trials with humans as a treatment for diabetes and obesity. "Importantly, the doses we have shown to be effective in stimulating tissue regeneration are 5–50-times lower than the maximum well-tolerated human dose."
taneq 7y ago
Wait till the mice hear about this one!

aussieguy1234 7y ago

Zebrafish != Humans

sheeshkebab 7y ago
It passed phase 1 trial in humans as well.

samairr8 7y ago

msi company is very good thanks for sharing][/url] [url=https://www.coinhashreports.com/2019/03/best-free-monero-cloud-mining-in-2019.html]free https://www.coinhashreports.com/2019/03/best-free-monero-clo... monero cloud mining[/url]

ur-whale 7y ago

Legitimate question : how hard would it be to synthesize in one's garage?

kirykl 7y ago

I wonder how this would affect patients whom have had cardiac ablation, possibly causing unwanted cellular re-growth

defterGoose 7y ago

ITT: People who read nothing past the first paragraph saying, 'Yeah, but only in zebrafish ppl'