> To my mind, the most hackable flaw is that the number of subjects in the study is a term in the denominator of the p-value calculation. Any study with a suffi

> To my mind, the most hackable flaw is that the number of subjects in the study is a term in the denominator of the p-value calculation. Any study with a sufficiently large sample will find "significance" with p<.05, but it won't be meaningful. Just to clarify. Any study with a sufficiently large sample will find a real effect even if the effect isn't clinically significant.