It seems Berberine and Metformin have different activation paths (Berberine might not lead to AMPK activation) and don't necessarily have exactly the same effec

It seems Berberine and Metformin have different activation paths (Berberine might not lead to AMPK activation) and don't necessarily have exactly the same effects. Is there any research on the two being comparable for longevity purposes (other than lowering tumor risk)?