5 ms·
"Sure, go for it" sure sounds like the next Opioid epidemic.
by outside1234 7y ago
"Sure, go for it" sure sounds like the next Opioid epidemic.
- toomuchtodo 7y agoMetformin is fairly safe as far as pharma goes; it requires a high dosage to be toxic, and the primary side effect is gastrointestinal distress. It's also a cheap generic (~5 cents/pill, costs me $2/month). It would be unfair to lump it in with the opioid epidemic, considering the differences. Would you not at least try to live a bit longer for only $25/year and a once a day pill?
- scottlocklin 7y agoBerberine is OTC. Not sure what relative risk profiles are. But yes, it's absolutely not comparable to opioids.
- deleted 7y ago[deleted]
- mdorazio 7y agoIt seems Berberine and Metformin have different activation paths (Berberine might not lead to AMPK activation) and don't necessarily have exactly the same effects. Is there any research on the two being comparable for longevity purposes (other than lowering tumor risk)?
- NickPlatt 7y agohttps://lifespanbook.com/metformin-pill/ https://lifespanbook.com/metformin-pill/
- NeoBasilisk 7y agoOh, I already have IBS, so that's a hard pass for me.
- toomuchtodo 7y agoDoesn't happen to everyone, and if does occur, it usually subsides after a week, but I would not recommend to someone who has IBS.