Firstly calories in, calories out is still in effect there. The toxin inhibited the calories in part. "In" doesn't mean "in your mouth" it means metabolised. S

Firstly calories in, calories out is still in effect there. The toxin inhibited the calories in part. "In" doesn't mean "in your mouth" it means metabolised. Secondly, obviously none of these people are referring to eating poison when they say where you get calories doesn't matter in terms of weight management. They are talking about people eating things that are plausibly going to be eaten by someone in a modern society, not people wandering the outback with no idea what they are doing. For similar reasons they also don't append "for individuals with something approximating normal metabolic function" every time they say say it. Using the above story as evidence against calories in/calories out for weight management is missing the forest for the trees.