Agreed. I think the purpose of papers like this is not to advocate for the therapy today, but to encourage scientists and research funding figures to more seri

Agreed. I think the purpose of papers like this is not to advocate for the therapy today, but to encourage scientists and research funding figures to more seriously investigate the phenomenon. As others here have noted, the past studies have been quite small, and because the treated study participants experience hunger, adding a blinded control group is difficult. These faults will have to be addressed before results are actionable clinically. But if they appear promising, there may be creative ways to address them, if the researchers do get sufficient motivation and funding.