I once had RSI so bad I could barely type for over a year. I swear by these mice: https://www.logitech.com/en-us/product/wireless-trackball-m570 https://www.lo

I once had RSI so bad I could barely type for over a year. I swear by these mice: https://www.logitech.com/en-us/product/wireless-trackball-m570 https://www.logitech.com/en-us/product/wireless-trackball-m5... You don't move your hand.. just rest your hand on it and lightly move your thumb by less than an inch in any direction (half inch typically.. if you're moving it much more than that, increase your pointer speed). There are ball mice that use your middle fingers, but I find those put stress on the tendons on the top of your hand. Add a keyboard that requires very little force to press the keys. I use this one (without the number pad).. it's decent: https://www.microsoft.com/accessories/en-us/products/keyboards/sculpt-ergonomic-desktop/l5v-00001 https://www.microsoft.com/accessories/en-us/products/keyboar... I don't know that the split in the keyboard matters all that much.. I think the pressure required to press the keys is the most important. Buy whatever kb you like with soft keys. I also have an articulating keyboard tray: https://www.amazon.com/Bush-Business-Furniture-Articulating-Keyboard/dp/B0000C0XP5 https://www.amazon.com/Bush-Business-Furniture-Articulating-... That lets you move the tray in every direction (back&forth, up&down, side to side, and tilt angle) so you can position the keyboard where it's suppose to be. Add a computer chair.. and you can position everything... even if your posture, etc isn't the best it could be every day.