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Genetics may explain up to 25% of same-sex behavior, giant analysis reveals
- drocer88 7y agoActual paper here : https://science.sciencemag.org/content/365/6456/eaat7693 https://science.sciencemag.org/content/365/6456/eaat7693 Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior. RESULTS In the discovery samples (UK Biobank and 23andMe), five autosomal loci were significantly associated with same-sex sexual behavior. Follow-up of these loci suggested links to biological pathways that involve sex hormone regulation and olfaction. Three of the loci were significant in a meta-analysis of smaller, independent replication samples. Although only a few loci passed the stringent statistical corrections for genome-wide multiple testing and were replicated in other samples, our analyses show that many loci underlie same-sex sexual behavior in both sexes. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in male and female same-sex sexual behavior, and the genetic influences were positively but imperfectly correlated between the sexes [genetic correlation coefficient (rg)= 0.63; 95% confidence intervals, 0.48 to 0.78].osteoblast SUPPLEMENTAL DATA HERE: https://science.sciencemag.org/content/suppl/2019/08/28/365.6456.eaat7693.DC1 https://science.sciencemag.org/content/suppl/2019/08/28/365....] TOP 20 genes from supplement are: ELAVL4 LRCH1 OR5A1 OR4D6 CD276 ADK CTNNB1 TCF4 OR5AN1 LRRTM4 PRKD1 OR2B2 HIST1H2BN TMEM258 OSBP2 Osteoblast differentiation ,myogenesis ,Wnt/B-catenin Signaling and olfactory signaling appear to be important pathways affected. 4 of the genes are on chr11q12 .
- cristinabunea 7y agoIf you want to listen to this article in audio, here’s a link: https://www.listle.io/#/article/894642610 https://www.listle.io/#/article/894642610