I agree that synergy is an important element, but to me a study like this could make sense even without synergy: To me, it seems better to have 4x the statistic

I agree that synergy is an important element, but to me a study like this could make sense even without synergy: To me, it seems better to have 4x the statistical data on 4 drugs at once than just running the individual studies, given how long a study like this takes.