"Conversely, continuous CR has also been associated with depleted circulating leukocytes, immunosuppression, and reduced bone density (Devlin et al., 2010; Ritz

"Conversely, continuous CR has also been associated with depleted circulating leukocytes, immunosuppression, and reduced bone density (Devlin et al., 2010; Ritz et al., 2008; Tang et al., 2016; Villareal et al., 2016)." (CR = caloric restriction)