The caloric reduction makes the difference, as the paper notes: > Of all the anti-aging and longevity-promoting interventions tested so far, calorie restrictio

The caloric reduction makes the difference, as the paper notes: > Of all the anti-aging and longevity-promoting interventions tested so far, calorie restriction (CR) seems to be the most conserved among species and robust. However, humans struggle to constantly achieve a certain level of CR. Here, we show in a clinical trial that a related intervention, alternate day fasting (ADF), also leads to striking reduction in overall calorie intake over the course of the study but is more easily tolerated than continuous CR and provokes similar beneficial changes on the cardiovascular system and on body composition while being safe for a period of >6 months.