5 ms·
The condition "diverse multinational cohort" is very important. The primary driver of population level variance in dairy consumption is lactose tolerance. For e
by dcolkitt 7y ago
The condition "diverse multinational cohort" is very important. The primary driver of population level variance in dairy consumption is lactose tolerance. For example Northern Europeans have much higher lactose tolerance than Aboriginal Australians.
So, we have to be really careful that dairy consumption isn't just proxying for ancestry. Because there are huge genetic variations in CVD mortality across different sub-populations. For example African-Americans have signficantly higher CVD, BP and diabetes risk because of higher rates of APOL1 polymorphism.
[1]https://jasn.asnjournals.org/content/26/2/247 https://jasn.asnjournals.org/content/26/2/247
- nostromo 7y agoI suspect lactose intolerance in the US is inversely correlated with wealth -- so this could just be another study showing that wealthy folks live longer.
- mac01021 7y ago> actose intolerance in the US is inversely correlated with wealth I'm not well informed about the causes of lactose intolerance. Is this correlation diet-induced/environmental? Or is it a congenital/racial thing where white people be rich and everyone else is genetically intolerant?
- shafyy 7y agoThe latter.
- mr_toad 7y agoLactose intolerance is the norm. Tolerance is unusual in adult mammals. In humans, it appears to be a very recent mutation, probably associated with the domestication of livestock. https://en.wikipedia.org/wiki/Lactase_persistence https://en.wikipedia.org/wiki/Lactase_persistence