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Careful, in addition to constricting/hardening blood vessels that is thought to lead to heart disease nicotine has other long term effects as seen in in this st

by mzs 7y ago

Careful, in addition to constricting/hardening blood vessels that is thought to lead to heart disease nicotine has other long term effects as seen in in this study of angiogenesis: >In a series of experiments, the researchers found that nicotine could enhance new blood vessel growth in mice whose hind limbs were artificially starved of oxygen. They also found that lung cancer cells implanted into mice grew more quickly when the mice consumed nicotine in their drinking water. Mice susceptible to developing plaque in the arteries of their hearts also experienced more rapid plaque growth when exposed to nicotine than mice who were not exposed. >The researchers believe nicotine works by binding to a receptor on the surface of endothelial cells that recognizes acetylcholine -- a chemical that nerve cells use to communicate with each other. Endothelial cells line the interior of blood vessels throughout the body. … https://news.stanford.edu/news/2001/july11/nicotine.html https://news.stanford.edu/news/2001/july11/nicotine.html

mikelyons 7y ago
Nicotine is also, itself, a known carcinogen.
- wyre 7y ago
  May I ask for a source on that? AFAIK the reason why cigarettes cause disease is because of the tar and all of the other byproducts of the Burning tobacco and that nicotine by itself is not the cause. I can't find a source of the top of my head but I smoked cigarettes for 4 years and enjoyed reading on them.
  - mikelyons 7y ago
    Ah, thanks HN community for correcting me! > At present, it is not possible to draw a conclusion whether nicotine itself may act as a complete carcinogen. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/
    - Balgair 7y ago
      In case anyone on HN reads this as saying that nicotine is safe to use, the end of that article is fairly clear: > Although more studies on health effects of nicotine in humans are required, based on in vitro and in vivo effects of nicotine, patients should be advised not to use nicotine products during cancer treatment unless it is temporarily needed to stop tobacco smoking.
- jdietrich 7y ago
  Not according to the IARC. https://monographs.iarc.fr/list-of-classifications https://monographs.iarc.fr/list-of-classifications

by mzs 7y ago

mikelyons 7y ago

Nicotine is also, itself, a known carcinogen.

wyre 7y ago
May I ask for a source on that? AFAIK the reason why cigarettes cause disease is because of the tar and all of the other byproducts of the Burning tobacco and that nicotine by itself is not the cause. I can't find a source of the top of my head but I smoked cigarettes for 4 years and enjoyed reading on them.
- mikelyons 7y ago
  Ah, thanks HN community for correcting me! > At present, it is not possible to draw a conclusion whether nicotine itself may act as a complete carcinogen. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553893/
  - Balgair 7y ago
    In case anyone on HN reads this as saying that nicotine is safe to use, the end of that article is fairly clear: > Although more studies on health effects of nicotine in humans are required, based on in vitro and in vivo effects of nicotine, patients should be advised not to use nicotine products during cancer treatment unless it is temporarily needed to stop tobacco smoking.
jdietrich 7y ago
Not according to the IARC. https://monographs.iarc.fr/list-of-classifications https://monographs.iarc.fr/list-of-classifications