3 ms·

I'm a little confused - can someone knowledgable in the area help out? In the introduction they assert: "Once inhaled, ultrafine particles and the oxidant spec

I'm a little confused - can someone knowledgable in the area help out? In the introduction they assert: "Once inhaled, ultrafine particles and the oxidant species located on their surface can translocate into the vascular space (13), resulting in a state of chronic vascular inflammation and oxidative stress noxious to endothelial function." However in the conclusion they state: "Inhaling nicotine-free electronic cigarette aerosol transiently impacted endothelial function in healthy nonsmokers" It sounds like in the introduction they are aware of studies that concluded the aerosol inhalation causes chronic issues with endothelial function, but they concluded that it only has a transient effect. Are they refuting those claims? Did I miss something?

zaptheimpaler 7y ago
Maybe the duration of the study is too short to definitively conclude a chronic effect, even though they suspect it is there.
onemoresoop 7y ago
While I don't think e-cigarettes are completely harmless, anything can be proved (fudged in a way) if there is an intention to. Yes, we don't know what the effects of vaping are but they appear to be a decent (and possibly more addictive) alternative to tobacco smokers who can't quit.
close04 7y ago
Transient in healthy nonsmokers. Since most vapers do it regularly it's a fair to assume that they are in a "permanently transient" state. A permanently acute state is basically a chronic state.
- filoleg 7y ago
  Imo permanent === persisting after whatever was causing this state in the first place is gone. If those "transient" effects are gone after a chronic user is done using after a long time, then I would still consider the effect to be transient rather than permanent.
  - close04 7y ago
    The study is about the transient effects of vaping on healthy never-smokers. The chronic effects were observed as part of other studies and just cited here.

zaptheimpaler 7y ago

Maybe the duration of the study is too short to definitively conclude a chronic effect, even though they suspect it is there.

onemoresoop 7y ago

While I don't think e-cigarettes are completely harmless, anything can be proved (fudged in a way) if there is an intention to. Yes, we don't know what the effects of vaping are but they appear to be a decent (and possibly more addictive) alternative to tobacco smokers who can't quit.

close04 7y ago

Transient in healthy nonsmokers. Since most vapers do it regularly it's a fair to assume that they are in a "permanently transient" state. A permanently acute state is basically a chronic state.

filoleg 7y ago
Imo permanent === persisting after whatever was causing this state in the first place is gone. If those "transient" effects are gone after a chronic user is done using after a long time, then I would still consider the effect to be transient rather than permanent.
- close04 7y ago
  The study is about the transient effects of vaping on healthy never-smokers. The chronic effects were observed as part of other studies and just cited here.