TB generally, and XDR TB specifically, are quite dangerous on a global scale. "By the end of 2016, XDR-TB has been reported by 123 WHO Member States. Informati

TB generally, and XDR TB specifically, are quite dangerous on a global scale. "By the end of 2016, XDR-TB has been reported by 123 WHO Member States. Information from countries with reliable data suggests that about 6.2% of MDR-TB cases worldwide have XDR-TB. In 2016, there were an estimated 490 000 new cases of MDR-TB worldwide. Only a small proportion of the XDR-TB cases among them are detected given that many low and lower middle-income countries still lack sufficient diagnostic capacity to test for resistance to second-line drugs and thus detect XDR-TB." In a study in South Africa, MDR-TB had a case fatality rate of about 9% in HIV- individuals, and 20% in HIV+ individuals.