4 ms·
I agree. Above I mention that neurons have finite resources so synaptic strength is essentially zero-sum. When a new set of synapses becomes strengthened, it im
by subroutine 7y ago
I agree. Above I mention that neurons have finite resources so synaptic strength is essentially zero-sum. When a new set of synapses becomes strengthened, it implies that all the other synapses must be weakened by some amount.
Here is a nice animation of signal propagation in biological neural nets:
https://youtu.be/WCqNn9PEELw https://youtu.be/WCqNn9PEELw
To simulate the dynamics of synaptic strength I created 3D mesh of a dendrite segment with several synapses...
https://youtu.be/tDKUU0SqbSA https://youtu.be/tDKUU0SqbSA
Then I simulate the diffusion of AMPA receptors on the surface (the number of AMPAR in a synapse is proportional to its strength)...
https://youtu.be/6ZNnBGgea0Y https://youtu.be/6ZNnBGgea0Y
I don't have animations of this process but you can imagine what happens when one synapse holds onto receptors longer than the others (has a reduced particle diffusion rate), when there are a finite number of receptors
- hos234 7y agoMaybe Glial cells are playing a role - https://www.sciencedaily.com/releases/2018/06/180618222427.htm https://www.sciencedaily.com/releases/2018/06/180618222427.h...
- subroutine 7y ago> In cell culture studies, they added neurons to astrocytes that overexpressed ephrin-B1 and were able to see synapse removal, with the astrocytes "eating up" the synapses... "We think that astrocytes expressing too much of ephrin-B1 can attack neurons and remove synapses" Yeah that would be a problem. Maybe Glial cells play a role, maybe they don't, opinions vary. https://streamable.com/1vi7r https://streamable.com/1vi7r