I would bet that it's easier to design an orbital or moon-based structure (depending on whether production benefits from or suffers from microgravity) that's he

I would bet that it's easier to design an orbital or moon-based structure (depending on whether production benefits from or suffers from microgravity) that's heavily shielded with lead, than it would be to create a deep-space-class hard vacuum in a volume of space on Earth suitable for large-scale industrial processes. It's a simple matter of not making the structure airtight. Given the volume and mass payload capabilities of the upcoming Starship/Superheavy, cheaply lifting bulk quantities of lead into space may actually be a reasonable proposal in the next five years rather than ultra-expensive pie-in-the-sky fantasy as it was during the age of disposable rockets.