Since you are specifically asking about split keyboards: I use a Kinesis Freestyle 2 and have done so at work for years. I use regular keyboards at home. - not

Since you are specifically asking about split keyboards: I use a Kinesis Freestyle 2 and have done so at work for years. I use regular keyboards at home. - not really any difficulty in terms of muscle memory remembering how to switch between regular and split keyboard - it did take me some retraining because before using a split keyboard I had actually typed 6 button with right hand instead of left - it does make a notable difference in terms of wrist pain after extended usage Overall, I can recommend it, especially if work is paying for it. I don’t type enough at home to really justify one though as I don’t start getting wrist pain unless I’m at the desk for 6-8 hours.