Many of them are full agonists on the cannabanoid receptors, which leads to GABA levels that are dangerously low when the receptors are saturated. THC proper lo

Many of them are full agonists on the cannabanoid receptors, which leads to GABA levels that are dangerously low when the receptors are saturated. THC proper lowers GABA somewhat, but not nearly as much. They've lead to seizures and have been linked to at least a few deaths.