About the safety: https://www.vice.com/en_us/article/nzdnak/why-ketamine-is-the-best-drug-on-earth https://www.vice.com/en_us/article/nzdnak/why-ketamine-is-th

About the safety: https://www.vice.com/en_us/article/nzdnak/why-ketamine-is-the-best-drug-on-earth https://www.vice.com/en_us/article/nzdnak/why-ketamine-is-th... So the half S, half R compound (I assume "esketamine" is S ketamine and "arketamine" R ketamine) is a commonly used drug in every emergency unit, probably in much higher doses than the ones used for depression. Using the S half only seems a way to get it patented. The concern seems to be that a nasal spray could lead to addiction beacuse fast assimilation. People that have used it illegally tell me that tolerance builds up very quickly, but they're talking about high (K-hole) doses. They don't use it often, just once in a month and mostly the racemate. They say esketamine only is weird and a little scary. The R half is what gives the happines feeling and mild hallucinogen effect, while the S half is the cause for depersonalization. A curious detail: the gq article says it's administered IV, while in vice article it's said that IV is dangerous because laryngospasm.