4 ms·
The complex system argument is a strawman. It’s well understood that complex traits are polygenic (no single gene or sets of causal variants) but quite easy to
by stanfordkid 7y ago
The complex system argument is a strawman.
It’s well understood that complex traits are polygenic (no single gene or sets of causal variants) but quite easy to predict such traits when looking at the full genome (I agree the resolution of prediction is still not there — but we are in the infancy of this field).
I recommend learning more about some of the polygenic risk scoring methodologies that are popping up in research:
https://www.broadinstitute.org/news/giant-study-finds-rare-influential-genetic-changes-related-height https://www.broadinstitute.org/news/giant-study-finds-rare-i...
- stanfordkid 7y agoEDIT: Why height is relevant : "Why study height? Height is the “poster child” of complex genetic traits, meaning it is influenced by multiple genetic variants working together. It’s easy to measure, so makes a relatively simple model for understanding traits produced by not one gene, but many."