4 ms·
This was the most interesting part to me: "Scott Fraser and his lab worked with the research team to develop 3D imagery of the results. The images unexpectedly
by oppositelock 7y ago
This was the most interesting part to me:
"Scott Fraser and his lab worked with the research team to develop 3D imagery of the results. The images unexpectedly revealed that senescent cells often have two nuclei, and that they do not synthesize DNA."
Huh, the interesting part to me was that the senescent cells have two nuclei. Muscle cells fuse during development and have multiple nuclei, and they can't divide anymore either. I wonder if senescence happens due to mitosis being stopped short by some mechanism, and whether the multiple nuclei are a symptom or one mechanism by which cells enter senescence.
- gnode 7y agoIt sounds to me like these senescent cells have reached or completed telophase (construction of nuclear membranes after mitosis), yet cytokinesis (splitting of the cell) has been inhibited. Perhaps during mitosis some kind of genetic integrity check is performed and failure halts cytokinesis (or success enables it).
- echelon 7y agoYou don't want certain cells to continue to proliferate. The development lifecycle also ends once a cell has differentiated into its ultimate tissue type. You don't want everything to be forever pluripotent. Proliferation and pluripotency are classic markers for cancer.