I think that until you're able to emulate meatspace in every aspect with VR, you cannot replace face-to-face. Economic clusters aren't just valuable for people

I think that until you're able to emulate meatspace in every aspect with VR, you cannot replace face-to-face. Economic clusters aren't just valuable for people being in the same office. They produce value because people and ideas meet in bars and restaurants and coffee shops and backyards. All of this is stuff you'd need to replace to "disaggregate the knowledge economy". This is not something you can accomplish with GitHub and teleconferencing.