3 ms·
What does it mean to "silence" a mutation? If that particular gene is different compared to humans who don't have the same developmental condition, then is the
by fareesh 7y ago
What does it mean to "silence" a mutation? If that particular gene is different compared to humans who don't have the same developmental condition, then is the medicine able to instruct the cells to replicate in a way that ignores the mutation and not carry the defect created by the mutation?
Or does the medicine supplement the role of whatever that cell is supposed to do? (Assuming this affects some specific roles cells)
- sjg007 7y agoThere are two alleles for this gene. You get one from your mom and one from your dad. In this case one allele has a mutation that is causative. So you inject some anti-sense RNA matched to that mutation, it will bind to the mRNA of the transcribed mutated gene DNA. Since it is now bound up, the mRNA cannot be translated by the ribosome and turned into protein. This means that only the other allele (without the mutation) is translated into protein.