3 ms·

[Speculation] This is interesting to me because Crohn’s Disease (and Inflammatory Bowel Disease in general) is known to respond to certain antibiotics such as M

[Speculation] This is interesting to me because Crohn’s Disease (and Inflammatory Bowel Disease in general) is known to respond to certain antibiotics such as Metronidazole and Ciprofloxacin [1]. Maybe a analogous action is at play here. [1] https://www.hopkinsmedicine.org/inflammatory_bowel_disease_center/about_ibd/index.html https://www.hopkinsmedicine.org/inflammatory_bowel_disease_c...

ionwake 7y ago
could it also improve athritic conditions? I have heard they are related to gut biome aswell
pojzon 7y ago
Not sure if I understood correctly. Metronidazol helps to keep inflammation at bay ? Im asking because I was taking this antibiotic and Ive seen huge change in my skin inflammation, joint pains and bowel pains.
- rubyfan 7y ago
  Change for better or for worse?
  - pojzon 7y ago
    For better, funny enough I got it for completely different condition.
    - rubyfan 7y ago
      Did the cipro help long term or only during the treatment?
- WalterSear 7y ago
  Is Psoriasis a bowel disease? Successful treatment with bile acids and bioflavonoids suggests it is. https://sci-hub.tw/10.1016/j.clindermatol.2018.03.011 https://sci-hub.tw/10.1016/j.clindermatol.2018.03.011 Fwiw: The article actually suggests that Psoriasis, (and IMHO, by extension, potentially autoimmune disease in general), are associated with liver dysfunction, driven by bowel disease.
  - atombender 7y ago
    I've read that paper. It's fascinating. The research and resulting protocol is inspired by an earlier Hungarian study in 2003 [1] that was able to seemingly cure psoriasis in 79% of its 500 test subjects. We don't know for sure; but 2 years later, 58% were still in complete remission. To be clear, that's a completely unheard-of result in psoriasis research. All current, "mainstream" forms of treatment for psoriasis only treat the symptoms, not the cause. Even the newest, most advanced immune-suppressing biologics are merely stupid off buttons for the signaling misfiring that causes the superficial symptoms; meanwhile, psoriasis sufferers have much-higher-than-average incidences of cancer, liver disease, heart disease, IBD and so on. Treatments only keep the skin/joint symptoms at bay, and require the patient to continue taking the drugs, which tend to stop working after a while. Pretty excited about this direction in psoriasis research. [1] https://www.sciencedirect.com/science/article/pii/S0928468003000427 https://www.sciencedirect.com/science/article/pii/S092846800...
    - WalterSear 7y ago
      Fwiw, I've found infrared induced hyperthermia to be extremely useful, but it's gruelling, time consuming and has a very short period of effect. I've been performing it most days for ~12 months. "...nine cycles of whole-body hyperthermia (target body core temperature, 38.5 degrees C; duration, 50 min)... caused a significant reduction of all cytokines by 40-50%" https://www.ncbi.nlm.nih.gov/pubmed/19089489 https://www.ncbi.nlm.nih.gov/pubmed/19089489 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263304/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263304/ I started the protocol outlined in Dr. Ely's paper recently. It seems to have reduced my symptoms somewhat, but it's too early to tell for sure.

ionwake 7y ago

could it also improve athritic conditions? I have heard they are related to gut biome aswell

pojzon 7y ago

Not sure if I understood correctly. Metronidazol helps to keep inflammation at bay ? Im asking because I was taking this antibiotic and Ive seen huge change in my skin inflammation, joint pains and bowel pains.

rubyfan 7y ago
Change for better or for worse?
- pojzon 7y ago
  For better, funny enough I got it for completely different condition.
  - rubyfan 7y ago
    Did the cipro help long term or only during the treatment?
WalterSear 7y ago
Is Psoriasis a bowel disease? Successful treatment with bile acids and bioflavonoids suggests it is. https://sci-hub.tw/10.1016/j.clindermatol.2018.03.011 https://sci-hub.tw/10.1016/j.clindermatol.2018.03.011 Fwiw: The article actually suggests that Psoriasis, (and IMHO, by extension, potentially autoimmune disease in general), are associated with liver dysfunction, driven by bowel disease.
- atombender 7y ago
  I've read that paper. It's fascinating. The research and resulting protocol is inspired by an earlier Hungarian study in 2003 [1] that was able to seemingly cure psoriasis in 79% of its 500 test subjects. We don't know for sure; but 2 years later, 58% were still in complete remission. To be clear, that's a completely unheard-of result in psoriasis research. All current, "mainstream" forms of treatment for psoriasis only treat the symptoms, not the cause. Even the newest, most advanced immune-suppressing biologics are merely stupid off buttons for the signaling misfiring that causes the superficial symptoms; meanwhile, psoriasis sufferers have much-higher-than-average incidences of cancer, liver disease, heart disease, IBD and so on. Treatments only keep the skin/joint symptoms at bay, and require the patient to continue taking the drugs, which tend to stop working after a while. Pretty excited about this direction in psoriasis research. [1] https://www.sciencedirect.com/science/article/pii/S0928468003000427 https://www.sciencedirect.com/science/article/pii/S092846800...
  - WalterSear 7y ago
    Fwiw, I've found infrared induced hyperthermia to be extremely useful, but it's gruelling, time consuming and has a very short period of effect. I've been performing it most days for ~12 months. "...nine cycles of whole-body hyperthermia (target body core temperature, 38.5 degrees C; duration, 50 min)... caused a significant reduction of all cytokines by 40-50%" https://www.ncbi.nlm.nih.gov/pubmed/19089489 https://www.ncbi.nlm.nih.gov/pubmed/19089489 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263304/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263304/ I started the protocol outlined in Dr. Ely's paper recently. It seems to have reduced my symptoms somewhat, but it's too early to tell for sure.