That's an interesting hypothesis, but man, that's a seriously garbage paper. It's borderline satire. It repeatedly comes back to an argument along the lines of:

That's an interesting hypothesis, but man, that's a seriously garbage paper. It's borderline satire. It repeatedly comes back to an argument along the lines of: "Drug has side effect X. X is not inconsistent with disrupted metabolism." Well, shit, very few things are outright inconsistent with disrupted metabolism, unless you've 100% nailed down an alternative mechanism for the side effect.