It's not always an option, but simply using PyPy can massively reduce memory usage without needing to change your code at all. The PyPy site links to this blog

It's not always an option, but simply using PyPy can massively reduce memory usage without needing to change your code at all. The PyPy site links to this blog post (from 10 years ago) with some info: https://morepypy.blogspot.com/2009/10/gc-improvements.html https://morepypy.blogspot.com/2009/10/gc-improvements.html And a quick search found this relatively recent post that does some measurement of it: https://dev.nextthought.com/blog/2018/08/cpython-vs-pypy-memory-usage.html https://dev.nextthought.com/blog/2018/08/cpython-vs-pypy-mem...