It is possible, but it is a challenge. When I was in San Diego Car2Go helped a lot (short one-way car rentals), but they're gone now. I cycled from Clairemont M

It is possible, but it is a challenge. When I was in San Diego Car2Go helped a lot (short one-way car rentals), but they're gone now. I cycled from Clairemont Mesa to South Park regularly and that was brutal.