3 ms·
Using phages to treat infections (phage therapy) has traditionally been suppressed in the West, but is making a comeback with a few high-profile case studies in
by boldlybold 7y ago
Using phages to treat infections (phage therapy) has traditionally been suppressed in the West, but is making a comeback with a few high-profile case studies in recent years. Tom Patterson had an atb resistant Acinetobacter baumannii infection that was cured with phages [1]. His wife wrote a book about it (The Perfect Predator) that is a good read review of the field. More recently, a patient with cystic fibrosis was cured of a Mycobacterium abscessus infection with phage therapy [2].
These therapies are currently very expensive and time consuming, as they require custom testing of libraries of phage against the specific microbial isolate. There have not been any successful large scale clinical trials yet.
For a good review of the field (but behind academic paywall), see [3]
[1] https://aac.asm.org/content/61/10/e00954-17 https://aac.asm.org/content/61/10/e00954-17
[2] https://www.nature.com/articles/s41591-019-0437-z https://www.nature.com/articles/s41591-019-0437-z
[3] https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(19)30052-6 https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(1...