4 ms·
I had read somewhere that telomere length reduces each time a cell divides. Assuming that, telomere shortening rate is directly indicative of the number of tim
by alok-g 7y ago
I had read somewhere that telomere length reduces each time a cell divides. Assuming that, telomere shortening rate is directly indicative of the number of times cells have gone through division. Could that not mean that telomere shortening rate is just estimating cell division rates and the latter relate to life span for an entirely different reason? Is this or some other study show that shortening rate is a better predictor of life span than cell division rate?
- bufferoverflow 7y agoTelomeres eventually end, and that's the difference.
- alok-g 7y agoIt would help if you can explain more. If telomere's ending were of significance, then their lengths would be a good predictor of life span. The OP is saying that it's not the length but the shorting rate that counts.
- bufferoverflow 7y agoThe length too. We've known that for a while. The rate is this new discovery (though not really, we've known it since 2018). 2017: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425118/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425118/ 2012: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277142/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277142/