I lightly follow the current understanding of telomerase, which is responsible for adding back the “buffers” (telomeres) at the end of genes that RNA can’t copy

I lightly follow the current understanding of telomerase, which is responsible for adding back the “buffers” (telomeres) at the end of genes that RNA can’t copy. It was clear this was part of what we’d need for anti-aging treatment, but last I heard we didn’t understand the mechanisms or how to activate them. Is transcriptome part of this process? It wasn’t immediately clear from the article.