3 ms·
It is? Which? The only thing I’m familiar with is using BCG vaccine vs. Superficial bladder cancer. And that is an immuno therapy. A PTEN mutation allows mycob
by arkades 7y ago
It is? Which?
The only thing I’m familiar with is using BCG vaccine vs. Superficial bladder cancer. And that is an immuno therapy. A PTEN mutation allows mycobacterium to enter cancer cells preferentially, and then invites an immune response that the cancer cells themselves had evaded. PTEN is a common mutation and bladder cancer, but is not seen in healthy bladder urothelium.
Edit: I should have read the article before commenting. The virus in the article also does not attack the bladder cancer, it has exactly the same mechanism as BCG. Although hopefully it is reliant on a different targeting mechanism than the PTEN mutation.
- classichasclass 7y agoThis is probably still an improvement, though. I haven't seen it happen often, but I've certainly seen cases of BCG instillation backtrack into the central circulation (my first case of this actually seeded his bone marrow with it), and then you've got a case of TB. If there's less morbidity if that happens here, and I presume there is, that's still better.